Characterization of side population cells in human malignant mesothelioma cell lines
作者： Kiyonori Kai , Susan D’Costa , Byung-Il Yoon , Arnold R. Brody , Robert C. Sills
DOI: 10.1016/J.LUNGCAN.2010.04.020
关键词:
摘要: Side population (SP) assay composed of Hoechst 33342 staining and subsequent flow cytometric analysis has been widely utilized for characterizing putative cancer stem cells (CSCs) in various human malignancies. The present study was designed to evaluate the SP as a research tool mesothelial CSCs. A distinct fraction identified malignant mesothelioma (HMM) cell lines, ranging from 0.05 1.32%. sorted exhibited enhanced proliferation potentials higher expression stem-cell genes, compared non-SP (NSP) cells. Cisplatin treatment increased percentage HMM lines. However, tumorigenic potential immunodeficient mice similar that NSP These data indicated may not be appropriate enriching CSCs thus warrants development novel CSC study.
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