Evaluating the Effectiveness of an Antimicrobial Stewardship Program on Reducing the Incidence Rate of Healthcare-Associated Clostridium difficile Infection: A Non-Randomized, Stepped Wedge, Single-Site, Observational Study

作者: Giulio DiDiodato , Leslie McArthur

DOI: 10.1371/JOURNAL.PONE.0157671

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摘要: Background The incidence rate of healthcare-associated Clostridium difficile infection (HA-CDI) is estimated at 1 in 100 patients. Antibiotic exposure the most consistently reported risk factor for HA-CDI. Strategies to reduce HA-CDI have focused on reducing antibiotic utilization. Prospective audit and feedback a commonly used antimicrobial stewardship intervention (ASi). The impact this ASi equivocal. This study examines effectiveness prospective

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