Clinical Significance of Epidermal Growth Factor Receptors in Non-small Cell Lung Cancer and a Prognostic Role for HER2 Gene Copy Number in Female Patients

摘要: Introduction: To compare the efficacy of silver in situ hybridization (SISH) and immunohistochemistry (IHC) detecting HER2 alterations to investigate prevalence prognostic significance Erb family members non-small cell lung cancer (NSCLC). Methods: Stage I IIIA tumors from 335 patients with NSCLC were immunohistochemically tested for protein expression all members. Membranous was compared its gene copy number by SISH paraffin-embedded, formalin-fixed material. Correlations made clinicopathological variables. Results: Synchronous high immunohistochemical seen 8% tumor samples. There a significant correlation between ( p = 0.003). High nuclear HER3 correlated significantly numbers 0.015). In univariate analyses, highly negative indicator disease-specific survival women 0.005), whereas it did not show influence men 0.9). Neither polysomy chromosome 17 nor IHC member proteins as singles or pairs survival. multivariate analysis, epithelial cells 0.03) an independent factor female patients. Conclusions: does consistently identify likely have poor prognosis, provides superior information NSCLC. is predictor inferior primary