Value of animal models for predicting hypersensitivity reactions to medicinal products

摘要: Although hypersensitivity reactions induced by medicinal products and chemicals are relatively common, few predictive models available. A major difficulty is our currently limited understanding of the mechanisms involved, efforts should be paid to better defining drug immunogenicity, hapten formation immune effector mechanisms. second multiplicity clinical manifestations presumably due varying Available can only predict a these reactions. Anaphylaxis in guinea-pigs used for safety assessment macromolecules which neither humanized or human origin, whereas guinea-pig mouse detect majority contact sensitizers. In addition extensive validation existing models, promising avenues research expected found use novel animal particularly those using genetically modified animals, such as transgenic knock-out mice.