RASSF6 is a novel member of the RASSF family of tumor suppressors.
作者： N P C Allen , H Donninger , M D Vos , K Eckfeld , L Hesson
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摘要: RASSF family proteins are tumor suppressors that frequently downregulated during the development of human cancer. The best-characterized member is RASSF1A, which by promoter methylation in 40-90% primary tumors. We now identify and characterize a novel family, RASSF6. Like other members, RASSF6 possesses Ras Association domain binds activated Ras. Exogenous expression promoted apoptosis, synergized with K-Ras to induce cell death inhibited survival specific lines. Suppression enhanced tumorigenic phenotype lung line. Furthermore, often shares some similar overall properties as proteins. However, there significant differences biological activity between members including discrete tissue profile, killing specificity impact on signaling pathways. Moreover, may play role dictating degree inflammatory response respiratory syncytial virus. Thus, demonstrates effector suppressor but exhibits unique distinct from those members.
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Marcos Malumbres, Angel Pellicer, RAS pathways to cell cycle control and cell transformation Frontiers in Bioscience. ,vol. 3, pp. d887- 912 ,(1998) , 10.2741/A331
Patricia A. Solski, Lawrence A. Quilliam, Sarah G. Coats, Channing J. Der, Janice E. Buss, [33] Targeting proteins to membranes using signal sequences for lipid modification Methods in Enzymology. ,vol. 250, pp. 435- 454 ,(1995) , 10.1016/0076-6879(95)50089-8
Reinhard Dammann, Chun Li, Jung-Hoon Yoon, Philip L. Chin, Steven Bates, Gerd P. Pfeifer, Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nature Genetics. ,vol. 25, pp. 315- 319 ,(2000) , 10.1038/77083
James J. Fiordalisi, Ronald L. Johnson, Aylin S. Ülkü, Channing J. Der, Adrienne D. Cox, Mammalian expression vectors for Ras family proteins: generation and use of expression constructs to analyze Ras family function. Methods in Enzymology. ,vol. 332, pp. 3- 36 ,(2001) , 10.1016/S0076-6879(01)32189-4
Vira Bitko, Nicolle E Garmon, Tin Cao, Benjamin Estrada, John E Oakes, Robert N Lausch, Sailen Barik, Activation of cytokines and NF-kappa B in corneal epithelial cells infected by respiratory syncytial virus: potential relevance in ocular inflammation and respiratory infection BMC Microbiology. ,vol. 4, pp. 28- 28 ,(2004) , 10.1186/1471-2180-4-28
Reinhard Dammann, Stella Tommasi, Gerd P. Pfeifer, Sharon P. Wilczynski, Yian Wang, Zhongqiu Zhang, Ming You, Walter M. Tsark, Limin Liu, Jie Li, Tumor Susceptibility of Rassf1a Knockout Mice Cancer Research. ,vol. 65, pp. 92- 98 ,(2005)
Jeremy Hull, Kate Rowlands, Elizabeth Lockhart, Mike Sharland, Catrin Moore, Neil Hanchard, Dominic P. Kwiatkowski, Haplotype mapping of the bronchiolitis susceptibility locus near IL8. Human Genetics. ,vol. 114, pp. 272- 279 ,(2004) , 10.1007/S00439-003-1038-X
Sheelagh Frame, Allan Balmain, Integration of positive and negative growth signals during ras pathway activation in vivo. Current Opinion in Genetics & Development. ,vol. 10, pp. 106- 113 ,(2000) , 10.1016/S0959-437X(99)00052-0
C. A. Ellis, M. D. Vos, H. Howell, T. Vallecorsa, D. W. Fults, G. J. Clark, Rig is a novel Ras-related protein and potential neural tumor suppressor Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 9876- 9881 ,(2002) , 10.1073/PNAS.142193799
Jindong Chen, Weng-Onn Lui, Michele D Vos, Geoffrey J Clark, Masayuki Takahashi, Jacqueline Schoumans, Sok Kean Khoo, David Petillo, Todd Lavery, Jun Sugimura, Dewi Astuti, Chun Zhang, Susumu Kagawa, Eamonn R Maher, Catharina Larsson, Arthur S Alberts, Hiro-omi Kanayama, Bin Tean Teh, None, The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. Cancer Cell. ,vol. 4, pp. 405- 413 ,(2003) , 10.1016/S1535-6108(03)00269-1