Modeling psychiatric disorders at the cellular and network levels.
作者： K J Brennand , A Simone , N Tran , F H Gage
DOI: 10.1038/MP.2012.20
关键词:
摘要: Although psychiatric disorders such as autism spectrum disorders, schizophrenia and bipolar disorder affect a number of brain regions produce complex array clinical symptoms, basic phenotypes likely exist at the level single neurons simple networks. Being highly heritable, it is hypothesized that these are amenable to cell-based studies in vitro. Using induced pluripotent stem cell-derived and/or from fibroblasts, limitless numbers live human can now be generated patients with genetic background permissive disease state. We predict will ultimately contribute our understanding initiation, progression treatment disorders.
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