Myocardial ischemia, reperfusion, and infarction in chronically instrumented, intact, conscious, and unrestrained mice

作者: Heidi L. Lujan , Hussein Janbaih , Han-Zhong Feng , Jian-Ping Jin , Stephen E. DiCarlo

DOI: 10.1152/AJPREGU.00095.2012

关键词:

摘要: In the United States alone, National Heart, Lung, and Blood Institute (NHLBI) has invested several hundred million dollars in pursuit of myocardial infarct-sparing therapies. However, due largely to methodological limitations, this investment not produced any notable clinical application or cardioprotective therapy. Among major limitations is reliance on animal models that do mimic situation. context, limited use conscious concern. fact, whenever possible, studies cardiovascular physiology pathophysiology should be conducted conscious, complex avoid complications associated with anesthesia surgical trauma. The mouse significant advantages over other experimental for investigation inexpensive, a high throughput, presents ability one create genetically modified models. successful therapies anesthetized mice isolated hearts may more models, including mice. Accordingly, model ischemia reperfusion potential importance advancing concepts methods drive development Therefore, we describe, first time, an intact, unrestrained ischemia-reperfusion infarction. permits occlusion left anterior descending coronary artery free confounding influences anesthetics This methodology adopted ideas research.

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