Use of Immunoglobulins in Prevention and Treatment of Infection in Critically III Patients: Review and Critique

摘要: The study of the use standard intravenous immunoglobulin (IVIG) preparations as adjunctive therapy for seriously ill patients is motivated by need to restore G depleted because trauma or surgery and/or provide with specific antibodies various microorganisms. Whereas no clinical studies have shown that IVIG has therapeutic efficacy, some data suggest its prophylactic beneficial. Antisera prepared from individuals who are hyperimmunized biologically active, highly conserved core portion endotoxin gram-negative bacteria confer variable degrees protection in animal models and trials. Two trials monoclonal lipopolysaccharide been completed. Only subsets sepsis were protected antibodies, but results discrepant regard characteristics benefited administration these antibodies. Further will be necessary establish whether this can recommended critically patients.