Dynein: An ancient motor protein involved in multiple modes of transport
作者： Richard B. Vallee , John C. Williams , Dileep Varma , Lora E. Barnhart
DOI: 10.1002/NEU.10314
关键词:
摘要: Cytoplasmic dynein has long been thought to be responsible for retrograde axonal transport. As the number of cellular roles this multifunctional protein expanded, complexity its contribution transport increased. In article increasing evidence a role cytoplasmic in anterograde as well is discussed. The current status complex cargo-binding mechanism evaluated. Finally, recent genetic supporting and revealing neurodegenerative conditions reviewed.
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