Cytochrome P-450-dependent metabolism of xenobiotics. A comparative study of rat hepatic and plant microsomal metabolism.
作者： J.T. Borlakoglu , P. John
DOI: 10.1016/0742-8413(89)90121-7
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摘要: Abstract 1. A comparison was made between rat hepatic and plant microsomal cytochrome P-450 linked enzymic activities. 2. The results show that, compared with microsomes, protein concentrations were 165-fold higher, concentration 32-fold higher. 3. Rat Cytochrome enzyme activities 1765-fold 25-fold greater when microsomes using aldrin biphenyl as substrates, respectively. 4. Rats metabolised to 2- 4-hydroxybiphenyl, whereas plants produced only the latter metabolite. 5. Pretreatment of rats tissues biphenyl, Aroclor 1248 sodium salt phenobarbital increased significantly concentrations, P-450. 6. Unlike those unable metabolise halosubstituted biphenyls at measurable rates.
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