An Integrated Segmentation and Analysis Approach for QCT of the Knee to Determine Subchondral Bone Mineral Density and Texture

摘要: We have developed a new integrated approach for quantitative computed tomography of the knee in order to quantify bone mineral density (BMD) and subchondral structure. The present framework consists image acquisition reconstruction, 3-D segmentation, determination anatomic coordinate systems, reproducible positioning analysis volumes interest (VOI). Novel segmentation algorithms were identify growth plates tibia femur joint space with high reproducibility. Five different VOIs varying distance articular surface are defined epiphysis. Each VOI is further subdivided into medial lateral part. In each VOI, BMD determined. addition, texture performed on high-resolution (CT) reconstruction same CT scan Local global homogeneity, as well local anisotropy measured all VOIs. Overall short-term precision technique was evaluated using double measurements 20 osteoarthritic cadaveric human knees. Precision errors volume about 2–3% 3–5% tibia. 1–2% lower. Homogeneity parameters showed up 2% 4%.