Double-blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependency.

摘要: Abstract Objective To perform a double-blind, placebo-controlled, random assignment, parallel group, pharmacokinetically dosed study of lithium for adolescents with bipolar disorders (BP) and temporally secondary substance dependency (SDD). Method Subjects were 16.3 ± 1.2 years old comprehensively assessed during 6-week outpatient protocol that included weekly urine collection drug assays serum levels. Results Using both intent-to-treat ( N = 25) completer n 21) analyses, there significant differences on continuous categorical measures between the active placebo groups psychopathology assays. The mean scheduled level responders was 0.9 mEq/L Addiction to alcohol marijuana most frequent category SDD. Mean age at onset BP 9.6 3.9 SDD 15.3 1.3 years. There multigenerational mood in 96% multi-generational 56% families. Conclusions Lithium treatment an efficacious disorders. These results warrant replication long-term maintenance phase. 6-year interval strongly argues earliest recognition BP.