Smoking and Inflammatory Bowel Disease: A Meta-analysis

摘要: OBJECTIVE To assess whether there is a true effect of smoking on the 2 most prevalent forms inflammatory bowel disease (IBD): Crohn (CD) and ulcerative colitis (UC). METHODS For this meta-analysis, we searched multiple health care databases, including MEDLINE EMBASE (January 1980 to January 2006), examine relationship between IBD. Keywords included smoking, disease, Crohn's , . Data were abstracted using predefined inclusion exclusion criteria. An odds ratio (OR) was recalculated for each study random-effects model, combined OR calculated. RESULTS A total 245 articles obtained through an electronic search databases. Thirteen studies examined UC whereas 9 CD smoking. We found evidence association current (OR, 1.76; 95% confidence interval [CI], 1.40-2.22) former 1.79; CI, 1.37-2.34). Current had protective development when compared with controls 0.58; 0.45-0.75). CONCLUSION This first our knowledge, evaluate IBD accepted quality standards meta-analysis reporting. Our meta-analyses confirm that important environmental factor in differing effects CD. By criteria testing homogeneity, analysis provides estimate both these