Emotional tagging of memory formation--in the search for neural mechanisms.

摘要: Memory-related areas, such as the hippocampus, should be able to sort out more significant from less relevant aspects of an experience in order transform only earlier into long-term memory. We have recently suggested Emotional Tagging concept, according which activation amygdala emotionally arousing events mark important and aids enhancing synaptic plasticity other brain regions. Here, we review evidence both human animal studies that lend support hypothesis central role may play its formation. further speculate on potential neural mechanisms underlie emotional tagging. Long-term memory formation is considered involve lasting alterations efficacy, known plasticity. It has been two factors are crucial for obtaining a synapse-specific plasticity: (a) successful synapse-specific, protein synthesis-independent tag, (b) synapse-non-specific synthesis. The synthesis can then induce those synapses marked by tag. Interestingly hypothesis, it shown could transient long-lasting These recent findings seem fit well with hypothesis. seems reasonable assume triggers neuromodulatory systems, turn reduce threshold this facilitate transformation early- late-phase