Dialkylformamldines: depurination resistant N6-protecting group for deoxyadenosine

作者: B.C. Froehler , M.D. Matteucci

DOI: 10.1093/NAR/11.22.8031

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摘要: Sterically hindered N6-dialkylformamidine protected deoxyadenosine is more stable to acidic depurination than N6-benzoyldeoxyadenosine and potentially a valuable protecting group in the synthesis of deoxyoligonucleotides.

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