Infected cells and immune cells in the gastrointestinal tract of AIDS patients. An immunohistochemical study of 127 cases.
作者： A. JARRY , A. CORTEZ , E. RENÉ , F. MUZEAU , N. BROUSSE
DOI: 10.1111/J.1365-2559.1990.TB01081.X
关键词:
摘要: Human immunodeficiency virus (HIV) proteins were detected by immunohistochemistry in the duodenal and rectal mucosa of 30% 127 AIDS patients studied. HIV-infected cells present lamina propria 95% positive biopsies. They immune cells, either isolated lymphocytes macrophages (1-4 per biopsy) or dendritic reticulum forming a network germinal centres mucosal lymphoid follicles. HIV not found epithelium superficial epithelium. In two cases (5% biopsies), they glands: could be epithelial cells. This study confirms that gut can target organ for is mainly carried The phenotypic populations showed an inverse CD4/CD8 ratio propria, compared with normal controls. was independent presence probably responsible appearance opportunistic infections mucosa. An increase activated also noted patients.
sci-hub.se 参考文章(21)
Barbara E. Laughon, Dolph A. Druckman, Andrew Vernon, Thomas C. Quinn, B.Frank Polk, John F. Modlin, Robert H. Yolken, John G. Bartlett, Prevalence of enteric pathogens in homosexual men with and without acquired immunodeficiency syndrome. Gastroenterology. ,vol. 94, pp. 984- 993 ,(1988) , 10.1016/0016-5085(88)90557-4
R Vazeux, N Brousse, A Jarry, D Henin, C Marche, C Vedrenne, J Mikol, M Wolff, C Michon, W Rozenbaum, JF Bureau, L Montagnier, M Brahic, AIDS subacute encephalitis. Identification of HIV-infected cells. American Journal of Pathology. ,vol. 126, pp. 403- 410 ,(1987)
M. E. Harper, L. M. Marselle, R. C. Gallo, F. Wong-Staal, Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 772- 776 ,(1986) , 10.1073/PNAS.83.3.772
C. D. BARONI, F. PEZZELLA, M. MIROLO, L. P. RUCO, G. B. ROSSI, Immunohistochemical demonstration of p24 HTLV III major core protein in different cell types within lymph nodes from patients with lymphadenopathy syndrome (LAS). Histopathology. ,vol. 10, pp. 5- 13 ,(1986) , 10.1111/J.1365-2559.1986.TB02456.X
Donald P. Kotler, Scott C. Weaver, John A. Terzakis, Ultrastructural Features of Epithelial Cell Degeneration in Rectal Crypts of Patients with AIDS The American Journal of Surgical Pathology. ,vol. 10, pp. 531- 538 ,(1986) , 10.1097/00000478-198608000-00002
R Colebunders, K Lusakumuni, A M Nelson, P Gigase, I Lebughe, E van Marck, B Kapita, H Francis, J J Salaun, T C Quinn, Persistent diarrhoea in Zairian AIDS patients: an endoscopic and histological study. Gut. ,vol. 29, pp. 1687- 1691 ,(1988) , 10.1136/GUT.29.12.1687
S Koenig, H. Gendelman, J. Orenstein, M. Dal Canto, G. Pezeshkpour, M Yungbluth, F Janotta, A Aksamit, M. Martin, A. Fauci, Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy Science. ,vol. 233, pp. 1089- 1093 ,(1986) , 10.1126/SCIENCE.3016903
DONALD P. KOTLER, Enteropathy associated with the acquired immunodeficiency syndrome. Annals of Internal Medicine. ,vol. 101, pp. 421- 428 ,(1984) , 10.7326/0003-4819-101-4-421
JayA. Nelson, Catherine Reynolds-Kohler, William Margaretten, ClaytonA. Wiley, CharlesE. Reese, JayA. Levy, HUMAN IMMUNODEFICIENCY VIRUS DETECTED IN BOWEL EPITHELIUM FROM PATIENTS WITH GASTROINTESTINAL SYMPTOMS The Lancet. ,vol. 331, pp. 259- 262 ,(1988) , 10.1016/S0140-6736(88)90348-0
E. Ren�, C. Marche, B. Regnier, A. G. Saimot, J. L. Vilde, C. Perrone, C. Michon, M. Wolf, Th. Chevalier, Th. Vallot, F. Brun-Vesinet, B. Pangon, A. M. Deluol, F. Camus, C. Roze, J. P. Pignon, M. Mignon, S. Bonfils, Intestinal infections in patients with acquired immunodeficiency syndrome. A prospective study in 132 patients. Digestive Diseases and Sciences. ,vol. 34, pp. 773- 780 ,(1989) , 10.1007/BF01540353