Vitamin d supplementation for the treatment of acute childhood pneumonia: a systematic review.

摘要: Background. Studies have found an increased incidence of vitamin D deficiency in children with pneumonia; however, there is no conclusive data regarding the direct effect supplementation acute pneumonia. Methods. A comprehensive search was performed major electronic databases till September 2013. Randomized controlled trials (RCTs) comparing treatment D3 versus placebo ≤5 years old pneumonia were included. Results. Out 32 full text articles, 2 RCTs including 653 eligible for inclusion. One trial used a single 100,000 unit oral at onset There significant difference mean (±SD) number days to recovery between and arms ( id="x30" d="M241 635q53 94 -28.5t63.5 -76t33.5 -102.5t11 -116q0 -58 -11 -112.5t-34 -103.5t-63.5 -78.5t-94.5 -29.5t-95 28t-64.5 75t-34.5 102.5t-11 118.5q0 58 11.5 112.5t34.5 103t64.5 78t95.5 29.5zM238 602q-32 -55.5 -25t-35.5 -68t-17.5 -91t-5.5 -105 q0 -76 10 -138.5t37 -107.5t69 -45q32 55.5 25t35.5 68.5t17.5 91.5t5.5 105t-5.5 105.5t-18 92t-36 68t-56.5 24.5z" ). Another (1000 IU 1 year) 5 severe Median duration resolution similar two groups (intervention, 72 hours; placebo, 64 hours). Duration hospitalization time tachypnea, chest retractions, inability feed also comparable groups. Conclusions. Oral does not help under-five