Identification and treatment of estrogen responsive prostate tumors

作者: Mark Rubin , Kirsten Mertz

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摘要: The present invention is directed to specific chromosomal rearrangements that are associated with prostate tumors respond compounds acting at estrogen receptors. Patients having the TMPRSS2-ERG fusion, may be treated agonists of beta receptor or antagonists alpha receptor.

参考文章(163)
Christoph M Ahlers, William Figg, II, ETS-TMPRSS2 fusion gene products in prostate cancer. Cancer Biology & Therapy. ,vol. 5, pp. 254- 255 ,(2006) , 10.4161/CBT.5.3.2603
Kristiina Iljin, Maija Wolf, Henrik Edgren, Santosh Gupta, Sami Kilpinen, Rolf I. Skotheim, Mari Peltola, Frank Smit, Gerald Verhaegh, Jack Schalken, Matthias Nees, Olli Kallioniemi, TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. Cancer Research. ,vol. 66, pp. 10242- 10246 ,(2006) , 10.1158/0008-5472.CAN-06-1986
Felix Mitelman, Recurrent chromosome aberrations in cancer. Mutation Research-reviews in Mutation Research. ,vol. 462, pp. 247- 253 ,(2000) , 10.1016/S1383-5742(00)00006-5
Eli Eisenberg, Erez Y. Levanon, Human housekeeping genes are compact Trends in Genetics. ,vol. 19, pp. 362- 365 ,(2003) , 10.1016/S0168-9525(03)00140-9
Janni Mirosevich, Nan Gao, Robert J. Matusik, Expression of Foxa transcription factors in the developing and adult murine prostate. The Prostate. ,vol. 62, pp. 339- 352 ,(2005) , 10.1002/PROS.20131
Changmeng Cai, Chen-Lin Hsieh, Josephat Omwancha, Zhe Zheng, Shao-Yong Chen, Jean-Luc Baert, Lirim Shemshedini, ETV1 Is a Novel Androgen Receptor-Regulated Gene that Mediates Prostate Cancer Cell Invasion Molecular Endocrinology. ,vol. 21, pp. 1835- 1846 ,(2007) , 10.1210/ME.2006-0480
S.E. Ulbrich, M. Wierer, H.H.D. Meyer, A. Hartel, A. Didier, Characterisation of steroid receptor expression in the human prostate carcinoma cell line 22RV1 and quantification of androgen effects on mRNA regulation of prostate-specific genes. The Journal of Steroid Biochemistry and Molecular Biology. ,vol. 92, pp. 187- 197 ,(2004) , 10.1016/J.JSBMB.2004.07.004
Levi A. Garraway, Hans R. Widlund, Mark A. Rubin, Gad Getz, Aaron J. Berger, Sridhar Ramaswamy, Rameen Beroukhim, Danny A. Milner, Scott R. Granter, Jinyan Du, Charles Lee, Stephan N. Wagner, Cheng Li, Todd R. Golub, David L. Rimm, Matthew L. Meyerson, David E. Fisher, William R. Sellers, Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma Nature. ,vol. 436, pp. 117- 122 ,(2005) , 10.1038/NATURE03664
Scott A. Tomlins, Bharathi Laxman, Saravana M. Dhanasekaran, Beth E. Helgeson, Xuhong Cao, David S. Morris, Anjana Menon, Xiaojun Jing, Qi Cao, Bo Han, Jindan Yu, Lei Wang, James E. Montie, Mark A. Rubin, Kenneth J. Pienta, Diane Roulston, Rajal B. Shah, Sooryanarayana Varambally, Rohit Mehra, Arul M. Chinnaiyan, Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer Nature. ,vol. 448, pp. 595- 599 ,(2007) , 10.1038/NATURE06024
Mark A Rubin, Arul M Chinnaiyan, Bioinformatics approach leads to the discovery of the TMPRSS2:ETS gene fusion in prostate cancer Laboratory Investigation. ,vol. 86, pp. 1099- 1102 ,(2006) , 10.1038/LABINVEST.3700477