Process for the preparation of 2-acylamino-6-halopurine from 2,9-diacylguanine

作者: Winfried Dr. Hertzsch

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摘要: 2-Acylamino-6-halopurine can be prepared by halogenation of 2,9-diacylguanine (2-acylamino-6-oxo-9-acylpurine) with phosphorus oxychloride or oxybromide in the presence a base and salt subsequent hydrolysis reaction product.

参考文章(2)
Henry Bader, Yunn H. Chiang, Method for preparing salts of 6-chloropurine ,(1981)
Michael Raymond Harnden, Richard Lewis Jarvest, Process for the preparation of 2-amino-6-chloro-purine ,(1986)