Polymorphism of HLA-DRB, -DQA1, and -DQB1 in Rheumatoid Arthritis in Asian Indians

摘要: Abstract We investigated the DRB, DQA1, and DQB1 polymorphism haplotypes in sporadic familial RA subjects of Asian Indian origin by PCR oligotyping using biotinylated SSOPs. Molecular subtyping DRB1 ∗ 04 patients showed strongest association with highest relative risk 0405, followed DRB 1 0401. A significant decreased frequency 1502 was observed compared to controls ( X 2 = 4.5). Among other alleles, 1001 found be significantly increased. total 73.3% carried shared sequence third HVR (67–74) domain its presence only 37.6% controls. number DR4 on 0302 (58%) as against 0301 which present 10.5% haplotypes. When controls, difference for latter allele only. Few unique DRDQ were Indians. DR-DQ haplotypes, 0401-DQB1 gave whereas 0403-DQB1 negatively associated. Alleles negative charge at position 70 confer protection or are associated among glycine 86 resulted higher than those valine this position. heterogenous alleles subtypes, influencing susceptibility RA, suggests DQB locus is not primarily lies 67–74 loci.