Disorganized vascular structures in sporadic venous malformations: a possible correlation with balancing effect between Tie2 and TGF-β.
作者： Gang Chen , Jian-Gang Ren , Wei Zhang , Yan-Fang Sun , Feng-Qin Wang
DOI: 10.1038/SREP05457
关键词:
摘要: Venous malformations (VMs) are among the most common slow-flow vascular characterized by irregular venous channels, luminal thrombi, and phleboliths. To systematically manifest disorganized structures in sporadic VMs, we initially evaluated histopathological characteristics, perivascular cell coverage, adhesion molecules expression ultrastructures. Then, of Tie2 TGF-β VMs was detected. Meanwhile, vitro studies were performed for mechanism investigation. Our data showed that α-SMA+ coverage significantly decreased compared with those normal skin tissues. We also found phosphorylation levels upregulated, whereas downregulated they negatively correlated. Moreover, results revealed a possible balancing effect between TGF-β, as demonstrated findings Ang-1 (agonist Tie2) treatment expression, recombinant could suppress phosphorylation. This study provided strong evidence supporting dysregulation related which might help to develop novel therapeutics disorganization-related disorders.
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