Diastereo- and Enantioselective Synthesis of β-Aminoboronate Esters by Copper(I)-Catalyzed 1,2-Addition of 1,1-Bis[(pinacolato)boryl]alkanes to Imines
作者： Jeongho Kim , Kwangwook Ko , Seung Hwan Cho
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摘要: Reported herein is an efficient copper(I)-catalytic system for the diastereo- and enantioselective 1,2-addition of 1,1-bis[(pinacolato)boryl]alkanes to protected imines afford synthetically valuable enantioenriched β-aminoboron compounds bearing contiguous stereogenic centers. The reaction exhibits a broad scope with respect 1,1-bis[(pinacolato)boryl]alkanes, thus providing β-aminoboronate esters excellent enantioselectivity. synthetic utility obtained ester was also demonstrated.
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