Stroke Propagates Bacterial Aspiration to Pneumonia in a Model of Cerebral Ischemia

摘要: Background and Purpose— Bacterial pneumonia is the most common cause of death in patients sustaining acute stroke believed to result from an increased aspiration. Recently, stroke-induced immunodeficiency was described a mouse model cerebral ischemia, which primarily caused by overactivation sympathetic nervous system. We tested if increases risk after aspiration newly developed poststroke pneumonia. Methods— Experimental mice induced occlusion middle artery (MCAO) for 60 minutes. Aspiration intranasal application 20 μL defined suspension Streptococcus pneumoniae phosphate-buffered saline 4 or 14 days MCAO. Treatment comprised moxifloxacin (100 mg/kg body weight, six times every 2 hours operation) propranolol (30 immediately before as well 8 MCAO). Readout lung histology bacterial counts blood. Results— Nasal inoculation only 200 colony-forming units S severe bacteremia experimental stroke, whereas 000 are needed induce comparable disease sham animals. animals outlasted state but preventable β-adrenoreceptor blockade. Conclusions— propagates harmless colonization harmful pneumonia. Prevention infections blockade suggests that immunodepression hyperactivity essential progression