Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a.
作者： Francesca Buontempo , Francesca Chiarini , Daniela Bressanin , Giovanna Tabellini , Fraia Melchionda
DOI: 10.4161/CC.20859
关键词:
摘要: Several lines of evidence suggest that the IκB kinase (IKK)/nuclear factor-κB (NFκB) axis is required for viability leukemic cells and a predictor relapse in T-cell acute lymphoblastic leukemia (T-ALL). Moreover, many anticancer agents induce NFκB nuclear translocation activation its target genes, which counteract cellular resistance to chemotherapeutic drugs. Therefore, design study IKK-specific drugs crucial inhibit tumor cell proliferation prevent cancer drug-resistance. Here, we report anti-proliferative effects induced by BMS-345541 (a highly selective IKK inhibitor) three Notch1-mutated T-ALL primary from pediatric patients. apoptosis an accumulation G2/M phase cycle via inhibition IKK/NFκB signaling. We also treated with displayed FOXO3a restoration functions, including control p21Cip1 express...
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