Separate and combined effects of genetic variants and pre-treatment whole blood gene expression on response to exposure-based cognitive behavioural therapy for anxiety disorders.

摘要: Objectives: Exposure-based cognitive behavioural therapy (eCBT) is an effective treatment for anxiety disorders. Response varies between individuals. Gene expression integrates genetic and environmental influences. We analysed the effect of gene markers separately together on response. Methods: Adult participants (n ≤ 181) diagnosed with panic disorder or a specific phobia underwent eCBT as part standard care. Percentage decrease in Clinical Global Impression severity rating was assessed across treatment, baseline 6-month follow-up. Associations response were using data from 3,233 probes, profiles clustered data- literature-driven manner. A total 3,343,497 variants used to predict alone combined polygenic risk scores. Genotype quantitative trait loci (eQTL) analyses. Results: Expression levels not associated either phenotype any analysis. 1,492 eQTLs identified q < 0.05, but interactions did affect significantly. Genetic significantly scores. Conclusions: alongside variants. No associations outcome identified. Future studies require larger sample sizes discover associations.