Impaired B-Cell Maturation Contributes to Reduced B Cell Numbers and Poor Prognosis in Sepsis.

摘要: Background Reduced B cell numbers play a critical role in sepsis immunosuppression. The of B-cell maturation regulated by T follicular helper (Tfh) cells reduced during remains unclear. We tested the hypothesis that impaired contributes to numbers. Design Retrospective study and observational prospective cohort study. Settings Critical care units. Methods To identify exact lymphocyte counts affect prognosis sepsis, we first conducted retrospective Then study, differences maturation, death, circulating Tfh (cTfh) were compared between 28-day survivors non-survivors, mainly flow cytometry enzyme-linked immunosorbent assay. Main results In (n = 123), found patients with less than 0.4 × 10 cells/L had higher mortality above cells/L. 40), survivors, non-survivors fewer mature (sepsis onset: memory cells: 3.44% vs. 4.48%, antibody-secreting 4.53% 6.30%, cTfh 3.57% 4.49%; 24 h after 4.05% 7.20%, 5.25% 8.78%, 3.98% 6.15%), while there no death them. further noticed positively correlated immunoglobulin concentrations. Conclusions Impaired numbers, cell, acting as warning indicator for prognosis, may be new therapeutic target treating sepsis.