Prostaglandin endoperoxide synthase: structure and catalysis
作者： William L. Smith , Lawrence J. Marnett
DOI: 10.1016/0005-2760(91)90119-3
关键词:
摘要: In this review, we describe the properties of PGH synthase, enzyme which catalyzes committed step in synthesis prostaglandins and thromboxane. We begin by presenting an overview protanoid biosynthesis mechanism action these local hormones. then novel characteristics two distinct reactions catalyzed synthase ― cyclooxygenase peroxidase interdependence transformations. Finally, summarize chemical physical protein, propose a model for active site
elsevier.com
sci-hub.se 参考文章(107)
D.L. DeWitt, T.E. Rollins, J.S. Day, J.A. Gauger, W.L. Smith, Orientation of the active site and antigenic determinants of prostaglandin endoperoxide synthase in the endoplasmic reticulum. Journal of Biological Chemistry. ,vol. 256, pp. 10375- 10382 ,(1981) , 10.1016/S0021-9258(19)68629-1
E. Christ-Hazelhof, D.H. Nugteren, [12] Isolation of PGH-PGD isomerase from rat spleen Methods in Enzymology. ,vol. 86, pp. 77- 84 ,(1982) , 10.1016/0076-6879(82)86172-7
F.J.G. van der Ouderaa, M. Buytenhek, [9] Purification of PGH synthase from sheep vesicular glands Methods in Enzymology. ,vol. 86, pp. 60- 68 ,(1982) , 10.1016/0076-6879(82)86169-7
R J Kulmacz, W E Lands, Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents. Journal of Biological Chemistry. ,vol. 260, pp. 12572- 12578 ,(1985) , 10.1016/S0021-9258(17)38909-3
Takao Shimizu, Shozo Yamamoto, Osamu Hayaishi, [11] Purification of PGH-PGD isomerase from rat brain Methods in Enzymology. ,vol. 86, pp. 73- 77 ,(1982) , 10.1016/0076-6879(82)86171-5
THE KINETICS OF THE ENZYME-SUBSTRATE COMPOUND OF PEROXIDASE Journal of Biological Chemistry. ,vol. 151, pp. 553- 577 ,(1943) , 10.1016/S0021-9258(18)44929-0
Philip George, Intermediate compound formation with peroxidase and strong oxidizing agents. Journal of Biological Chemistry. ,vol. 201, pp. 413- 426 ,(1953) , 10.1016/S0021-9258(18)71384-7
W R Pagels, R J Sachs, L J Marnett, D L Dewitt, J S Day, W L Smith, Immunochemical evidence for the involvement of prostaglandin H synthase in hydroperoxide-dependent oxidations by ram seminal vesicle microsomes. Journal of Biological Chemistry. ,vol. 258, pp. 6517- 6523 ,(1983) , 10.1016/S0021-9258(18)32442-6
G.J. Roth, C.J. Siok, J. Ozols, Structural characteristics of prostaglandin synthetase from sheep vesicular gland. Journal of Biological Chemistry. ,vol. 255, pp. 1301- 1304 ,(1980) , 10.1016/S0021-9258(19)86029-5
D L DeWitt, E A el-Harith, S A Kraemer, M J Andrews, E F Yao, R L Armstrong, W L Smith, The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases. Journal of Biological Chemistry. ,vol. 265, pp. 5192- 5198 ,(1990) , 10.1016/S0021-9258(19)34105-5