Treatment of Apnea of Prematurity

摘要: In the last decade, knowledge regarding neurodevelopment and functional aspects of respiratory centers during postnatal maturation has increased substantially. However, an increase in such not provided a basis for change practice. The diagnosis apnea prematurity (AOP) is one exclusion. All causes secondary must be ruled out before initiating treatment AOP. Treatment will depend on etiology as well effectiveness tolerability by patient. primary goal any AOP to prevent frequency lasting >20 seconds, and/or those that are shorter, but associated with cyanosis bradycardia. clinical management much different today than it was two decades ago, pharmacologic nonpharmacologic options remaining mainstay therapy. Methylxanthines still most widely used agents. Due wider therapeutic index caffeine ease once daily administration, should preferred agent. Doxapram, or measures nasal continuous positive airway pressure, may considered infants who unresponsive methylxanthine alone. continued until there complete resolution apnea, some time thereafter. choice method weaning remains individual physician preference. Discharge from hospital after requires close monitoring require home monitors. decision provide monitor individualized each patient, depending response.