Impact of Exposure of Methicillin-Resistant Staphylococcus aureus to Polyhexanide In Vitro and In Vivo.

摘要: Methicillin-resistant Staphylococcus aureus (MRSA) resistant to decolonization agents such as mupirocin and chlorhexidine increases the need for development of alternative molecules. The absence reported severe adverse reactions bacterial resistance polyhexanide makes it an excellent choice a topical antiseptic. In present study, we evaluated in vitro vivo capacity generate strains with reduced susceptibility cross-resistance and/or antibiotics currently used clinic. Here report emergence by prolonged stepwise exposure low concentrations broth culture. Reduced was associated genomic changes mprF purR genes concomitant decreased daptomycin other cell wall-active antibiotics. However, did not result chlorhexidine. During clinical treatment, neither nor observed. Together, these observations suggest that could be safely carriers chlorhexidine-resistant S. strains; they also highlight careful use at antiseptic concentrations.