Thyroid Dysfunction Associated With Follicular Cell Steatosis in Obese Male Mice and Humans

摘要: Adult thyroid dysfunction is a common endocrine disorder associated with an increased risk of cardiovascular disease and mortality. A recent epidemiologic study revealed link between obesity prevalence hypothyroidism. It conceivable that excessive adiposity in might lead to expansion the interfollicular adipose (IFA) depot or steatosis follicular cells (thyroid steatosis, TS). In this study, we investigated morphological functional changes glands obese humans animal models, diet-induced (DIO), ob/ob, db/db mice. Expanded IFA TS were observed patients. Furthermore, DIO mice showed expression lipogenesis-regulation genes, such as sterol regulatory element binding protein 1 (SREBP-1), peroxisome proliferator-activated receptor γ (PPARγ), acetyl coenzyme carboxylase (ACC), fatty acid synthetase (FASN) gland. Steatosis ultrastructural changes, including distension endo...