Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer's disease?

摘要: The assumption that disease specific risk factors are similar or the same in men and women may lead to incorrect primary prevention strategies. This study focused on evaluation of gender-specific Alzheimer's (AD) factors. In AD, female gender appears be an important factor associated with aberrant production beta amyloid (βA) peptides. Although decreased levels plasma DHA concentration cognitive decline healthy elderly patients, pre-treatment significantly reduced survival cortical neurons incubated (βA). Hence, presence increasing amount βA, paradoxically - who have higher more likely develop AD. Aspirin (ASA) converts cyclooxygenase (COX)-2 into a form generates new neuroprotective docosanoids from DHA; therefore, ASA might positively resolve paradoxical effect concomitant βA.