Assessment of DNA Damage and Protective Role of Vitamin E Supplements after Exhaustive Exercise by Comet Assay in Athletes
作者： Gulden Z Omurtag
关键词:
摘要: Exhaustive physical exercise is associated with an increased oxidative activity and antioxidants are widely used as supplements, to prevent the deleterious effects of endogenous reactive oxygen species. The purpose this study investigate induced DNA damage possible protective effect vitamin E supplementation. Comet assay was carried out in 23 athletes who were competitive rowers education students a Sports school. blood samples tested at baseline, 24h after performing maximal all subjects took antioxidant supplementation (vit 400 IU/day) for 60 days above tests repeated. mean percentage tail (% DNAT) rowers, higher than students, (8.32±0.51, 5.99±0.52, respectively). A significant decrease extent %DNAT observed compared their initial evaluations.
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Allan H. Goldfarb, Stephen W. Patrick, Scott Bryer, Tongjian You, Vitamin C supplementation affects oxidative-stress blood markers in response to a 30-minute run at 75% VO2max. International Journal of Sport Nutrition and Exercise Metabolism. ,vol. 15, pp. 279- 290 ,(2005) , 10.1123/IJSNEM.15.3.279
R. R. Tice, P. W. Andrews, N. P. Singh, The Single Cell Gel Assay: A Sensitive Technique for Evaluating Intercellular Differences in DNA Damage and Repair DNA Damage and Repair in Human Tissues. ,vol. 53, pp. 291- 301 ,(1990) , 10.1007/978-1-4613-0637-5_23
William J Evans, Vitamin E, vitamin C, and exercise. The American Journal of Clinical Nutrition. ,vol. 72, ,(2000) , 10.1093/AJCN/72.2.647S
Stefanie Reichhold, Oliver Neubauer, Christine Hoelzl, Barbara Stadlmayr, Judit Valentini, Franziska Ferk, Michael Kundi, Siegfried Knasmüller, Karl-Heinz Wagner, DNA damage in response to an Ironman triathlon. Free Radical Research. ,vol. 43, pp. 753- 760 ,(2009) , 10.1080/10715760903040628
Kelvin Tsai, Tai-Ger Hsu, Kuang-Ming Hsu, Hu Cheng, Tsung-Yun Liu, Chen-Fu Hsu, Chi-Woon Kong, Oxidative DNA damage in human peripheral leukocytes induced by massive aerobic exercise Free Radical Biology and Medicine. ,vol. 31, pp. 1465- 1472 ,(2001) , 10.1016/S0891-5849(01)00729-8
Karlis Briviba, Bernhard Watzl, Kerstin Nickel, Sabine Kulling, Klaus Bös, Sascha Haertel, Gerhard Rechkemmer, Achim Bub, A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners. Redox Report. ,vol. 10, pp. 325- 331 ,(2005) , 10.1179/135100005X83716
Semra Şardaş, Murat Yilmaz, Umut Öztok, Nuri Çakir, Ali Esat Karakaya, Assessment of DNA strand breakage by comet assay in diabetic patients and the role of antioxidant supplementation Mutation Research/Genetic Toxicology and Environmental Mutagenesis. ,vol. 490, pp. 123- 129 ,(2001) , 10.1016/S1383-5718(00)00157-1
AM Niess, A Hartmann, M Grünert-Fuchs, B Poch, G Speit, None, DNA damage after exhaustive treadmill running in trained and untrained men. International Journal of Sports Medicine. ,vol. 17, pp. 397- 403 ,(1996) , 10.1055/S-2007-972868
Keun Su Kim, Il Young Paik, Jin Hee Woo, Byung Yong Kang, The Effect of Training Type on Oxidative DNA Damage and Antioxidant Capacity during Three-Dimensional Space Exercise Medical Principles and Practice. ,vol. 19, pp. 133- 141 ,(2010) , 10.1159/000273075
Angela Mastaloudis, Tian-Wei Yu, Robert P. O'Donnell, Balz Frei, Roderick H. Dashwood, Maret G. Traber, Endurance exercise results in DNA damage as detected by the comet assay. Free Radical Biology and Medicine. ,vol. 36, pp. 966- 975 ,(2004) , 10.1016/J.FREERADBIOMED.2004.01.012