RASPoint Mutations and PAX8-PPARγ Rearrangement in Thyroid Tumors: Evidence for Distinct Molecular Pathways in Thyroid Follicular Carcinoma

摘要: A series of 88 conventional follicular and Hurthle cell thyroid tumors were analyzed for RAS mutations PAX8-PPARγ rearrangements using molecular methods galectin-3 HBME-1 expression by immunohistochemistry. novel LightCycler technology-based method was developed to detect point in codons 12/13 61 the H-RAS, K-RAS, N-RAS genes. Forty-nine percent carcinomas had mutations, 36% rearrangement, only one (3%) both. In adenomas, 48% 4% neither. Follicular with typically showed immunoreactivity but not HBME-1, tended present at a younger patient age be smaller size, almost always overtly invasive. contrast, most often displayed an HBME-1-positive/galectin-3-negative immunophenotype either minimally or infr...