Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease.
作者： Kelly A. Pike , Michel L. Tremblay
关键词:
摘要: Protein tyrosine phosphatases (PTPs) play a critical role in co-ordinating the signaling networks that maintain lymphocyte homeostasis and direct activation. By dephosphorylating residues, PTPs have been shown to modulate enzyme activity both mediate disrupt protein-protein interactions. Through these molecular mechanisms, ultimately impact responses environmental cues such as inflammatory cytokines chemokines, well antigenic stimulation. Mouse models of acute chronic intestinal inflammation be exacerbated absence PTPN2 PTPN22. This increase disease severity is due part hyper-activation lymphocytes PTP activity. In accordance, human linked inflammation. Genome wide association studies (GWAS) identified several within risk loci for bowel (IBD). Therapeutically targeting substrates their associated pathways, those implicated CD4+ T cell responses, has demonstrated clinical efficacy. The current review focuses on controlling mucosa how disruption cells can contribute
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