Use of triclabendazole for treatment of patients co-infected by Fasciola spp. and S. mansoni in Behera Governorate, Egypt.

摘要: Praziquantel is still very effective for the treatment of schistosomiasis, but there are rising concerns on potential risk developing resistances because extensive use this drug. Triclabendazole, a systemic anthelmintic, against other trematodes such as Paragonimus spp. and Fasciola It has been reported to be in vitro experimental animals Schistosoma mansoni. However, its antischistosomal efficacy humans not yet evaluated. The objective study was evaluate triclabendazole at dosage currently used human fascioliasis (10mg/kg body weight) subjects co-infected with S. mansoni carried out Behera, highly endemic area both parasites, by personnel Egyptian Ministry Health Population. Ten (m = 4, f 6; age, 8–58years), who were infected same time mansoni, enrolled. Six weeks after therapy, seven excreting ova whereas none ova. At given dosage, appeared sufficiently