Nimotuzumab as a radiosensitizing agent in the treatment of high grade glioma: challenges and opportunities
作者： Arlhee Díaz-Miqueli , Martinez
DOI: 10.2147/OTT.S33532
关键词:
摘要: Nimotuzumab is a humanized monoclonal antibody that binds specifically to human epidermal growth factor receptor, blocking receptor activation. Evidence of its radiosensitizing capacity has been widely evaluated. This article integrates published research findings regarding the role nimotuzumab in treatment high grade glioma combination with radiotherapy or radiochemotherapy adult and pediatric populations. First, mechanisms action current applications clinical trials containing both radiation chemoradiation therapies are reviewed. Second, comprehensive explanation potential driving radiosensitization by experimental settings given. Finally, future directions targeting regimens, based on favorable toxicity profile, proposed. It hoped this review may provide further insight into rational design new approaches employing as useful alternative for therapeutic management glioma.
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