Process hybridization schemes for multiscale engineered tissue biofabrication.

摘要: Recapitulation of multiscale structure-function properties cells, cell-secreted extracellular matrix, and 3D architecture natural tissues is central to engineering biomimetic tissue substitutes. Toward achieving biomimicry, a variety biofabrication processes have been developed, which can be broadly classified into five categories-fiber fabric formation, additive manufacturing, surface modification, remote fields, other notable processes-each with specific advantages limitations. The majority literature has focused on using single process at time, often limits the range that could created relevant features span nano macro scales. With biomimicry as goal, development hybrid strategies synergistically unite two or more complement each other's strengths limitations steadily increasing. This work discusses recent in this domain attempts equip reader understanding selecting appropriate harmonize toward creating engineered properties. Opportunities related various hybridization schemes future outlook scale-up also discussed. article categorized under: Nanotechnology Approaches Biology > Nanoscale Systems Implantable Materials Surgical Technologies Tissue Repair Replacement.