New dressings, including tissue-engineered living skin.

摘要: In humans, skin corresponds to one-tenth of the body mass, and damage a part this organ has critical consequences. Trauma, disease, burn or surgery can result in great difficulty heal affected area. Any significant loss dermis tends contract distort producing scar. Unfortunately, cannot just be transplanted like others organs requires other methods, such as reconstructive surgery, grafting procedure. Healing by second intention is common technique managing wound, but it an unpredictable cosmetic often prolongs healing time several weeks. Growing replacement tissues repair was science fiction past. The first experience took place 1907 when Harrison demonstrated that individual cells were capable live outside which they grown. our time, clonage reality. Different materials devices, specific interactions with biologic tissues, developed restore barrier function while permitting epidermal regrowth. Some are entirely synthetic; some combination materials, built from products. Many different wound dressings tissue-engineered now available. Tissue-engineered defined 1987 National Science Foundation Bioengineering Panel Meeting, Washington, DC, “the application principles methods engineering life sciences toward development substitutes restore, maintain, improve function.” At present, there no strict distinction between dressing substitutes. Generally, synthetic polymer synthetics associated component termed dressings, combine matrix proteins polymers consider exact definition very hard Biobrane, divided epidermis, dermis, hypodermis. totally cellular and, although thin, sufficient thickness provide vital function. right below constitutes bulk skin. upper layer based on extracellular predominantly collagen, elastin glycosaminoglycans; fibroblasts distributed through it, adhering collagen fibers also blood lymph vessel, nerve endings, structures. Fibroblasts enzymes, collagenases proteases “re-model” deposited collagen; important process latter stages wound-healing process. hypodermis located beneath containing considerable amount adipose tissue, provides mechanical thermal insulating properties combines novel living yield functional tissue equivalents, They matrix, required for Culturing fibroblast gels “lattices” produces structures known dermal equivalent, forms basis constructing equivalent. A equivalent constructed seeding into reformed, three-dimensional matrix. Layering keratinocytes surface structure It simplified model, represent step reconstruction.