The Role of gp130 Cytokines in Tuberculosis.

摘要: Protective immune responses to Mycobacterium tuberculosis (Mtb) infection substantially depend on a delicate balance within cytokine networks. Thus, immunosuppressive therapy by blockers, as successfully used in the management of various chronic inflammatory diseases, is often connected with an increased risk for (TB) reactivation. Hence, identification alternative therapeutics which allow treatment diseases without compromising anti-mycobacterial immunity remains important issue. On other hand, context novel therapeutic approaches TB, host-directed adjunct therapies, combine administration antibiotics immunomodulatory drugs, play increasingly role, particularly reduce duration treatment. In both respects, cytokines/cytokine receptors related common receptor subunit gp130 may serve promising target candidates. Within family, interleukin (IL)-6, IL-11 and IL-27 are most explored TB. This review summarizes differential roles these cytokines protection immunopathology during Mtb discusses potential implementations respect aforementioned approaches.