Liver-directed therapies in colorectal cancer

摘要: The liver is the most common site of metastatic colorectal cancer (CRC) and status this organ an important determinant overall survival in patients with advanced disease. Complete resection hepatic CRC metastases can provide a long-term cure for some patients, but majority are not amenable to such surgery. Furthermore, after curative ultimately suffer from recurrence, failures occur liver. Various ablative techniques achieve local control tumor incomplete or palliation. Tumor ablation currently has secondary therapeutic role, as there no evidence that it comparable surgical resection. Regional chemotherapy delivers tumoricidal agents selective fashion, minimizing systemic toxicity damage normal cells. Chemotherapy delivered through artery extend time recurrence may prolong both adjuvant setting when given unresectable Molecular-based therapies, gene delivery oncolytic viruses, promise outcomes