Quercetin-imprinted nanospheres as novel drug delivery devices.
作者： Manuela Curcio , Giuseppe Cirillo , Ortensia Ilaria Parisi , Francesca Iemma , Nevio Picci
DOI: 10.3390/JFB3020269
关键词:
摘要: In this work, molecularly imprinted nanospheres for controlled/sustained release of quercetin were synthesized employing methacrylic acid and ethylene glycoldymethacrylate as functional monomer crosslinking agent, respectively. One pot precipitation polymerization was chosen technique to obtain nanosized materials with spherical shape. Morphological hydrophilic properties by scanning electron microscopy water content measurements determined, recognition selectivity the tested using template its structural analogue, flavonoid catechin. Finally, applicability obtained drug delivery devices evaluated performing in vitro studies plasma simulating fluids cytotoxicity testson HeLa cells.
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