Fabrication of cyclodextrin nanosponges for quercetin delivery: physicochemical characterization, photostability, and antioxidant effects

摘要: Quercetin is a flavonoid widely distributed in vegetables and fruits exhibits strong antioxidant activity, but the poor solubility stability of quercetin limit its function application. The purpose this study was to enhance dissolution rate poorly water-soluble drug by complexation with cyclodextrin-based nanosponges. Nanosponges are recently developed sponge-like structures have capacity interact small molecules matrix. In study, five types nanosponges were purposely designed varying molar ratio β-cyclodextrin diphenyl carbonate. loaded into freeze-drying method. particle sizes plain quercetin-loaded between 40 100 nm low polydispersity indices. Zeta potential sufficiently high obtain stable colloidal nanosuspension. Fourier transformed infrared, Raman spectroscopy, differential scanning calorimetry, X-ray powder diffraction studies confirmed interaction Particle measured from TEM images agreement DLS results. significantly higher compared pure drug. encapsulated nanosponge tracked simulated intestinal fluid. A marked improvement photostability also observed. addition, activity more effective than on DPPH scavenging, anti-superoxide formation, superoxide anion scavenging. These results signify that formulations can be used as nanocarriers for delivery quercetin.