In vitro and in vivo comparison of the biological activities of two traditionally and widely used Arum species from Jordan: Arum dioscoridis Sibth & Sm. and Arum palaestinum Boiss.
作者： Fatma U. Afifi , Violet Kasabri , Simona C. Litescu , Ismail M. Abaza
DOI: 10.1080/14786419.2015.1072713
关键词:
摘要: Arum dioscoridis and A. palaestinum (Araceae) are indigenous plant species in Jordan. HPLC-MS analysis of revealed the presence apigenin, luteolin, quercetin, quercetin-3-O-β-glucoside, vitexin, isoorientin, esculin, caffeic ferulic acids. Both spp., influenced gastrointestinal carbohydrate lipid digestion absorption. Orlistat inhibited dose dependently highly substantially pancreatic lipase (PL) vitro. Similar to orlistat, aqueous extracts (AEs), acid esculin exhibited a concentration related PL inhibition. Comparable acarbose, dual inhibition α-amylase/α-glucosidase was observed for both species. Like guar gum, AE minimised area under 24 h glucose curve. Acute starch-induced postprandial hyperglycaemia overnight fasting rats significantly (p < 0.001) decreased by AE. could not perform effectively either starch- or glucose-fed rats. No antiproliferative effects against colorectal cancer cell lines HT29, HCT116 SW620 were detected tested spp.
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