Human proximal duodenal ion and water transport. Role of enteric nervous system and carbonic anhydrase.

摘要: Intestinal ion transport is mediated by the interaction of enterocyte function, enteric nervous system, humoral agents, and mucosal production carbonic anhydrase. Our purpose was to examine effect anhydrase inhibitor acetazolamide inhibition system with topical anesthetic lidocaine on basal prostaglandin E2-stimulated water transmucosal electrical potential difference. At rest, mean (95% confidence intervals) net secretion into human proximal duodenum was: Cl− 670 (288–1052), Na+ 818 (410–1225), K+ 32 (14–51) µmol/cm/hr. Basal 30 (14.6–45.3) ml/hr, difference (PD) 7.0 (3.6–10.9) mV, lumen negative. Intraluminal E2 increased all ions, water, PD. After pretreatment luminal administration lidocaine, unchanged, but response PGE2 inhibited. It concluded that: (1) at rest there a Na+, K+, Cl−, duodenum; (2) PGE2-stimulated electrolyte dependent in part upon activity system.