Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
作者： Yanyan Hao , Keiko Sekine , Atsushi Kawabata , Hitoshi Nakamura , Toshiyasu Ishioka
DOI: 10.1038/NCB1159
关键词:
摘要: Apollon (also known as BRUCE or BIRC6) is a large protein containing baculoviral-IAP-repeat (BIR) and ubiquitin-conjugating enzyme (UBC) domains at the amino- carboxy termini, respectively. inhibits apoptosis, but its molecular physiological function remains unclear. Here we report that binds to, ubiquitinates facilitates proteasomal degradation of SMAC caspase-9, which both contain IAP-binding motifs. Targeted disruption in mice caused embryonic neonatal lethality. Notably, induced apoptosis Apollon-deficient cells, not Apollon-expressing cells. Furthermore, motif was required to induce These results suggest has an essential preventing SMAC-induced apoptosis.
nature.com
unirioja.es
sci-hub.se 参考文章(44)
Mikihiko Naito, Kimie Nagashima, Tetsuo Mashima, Takashi Tsuruo, Phosphatidylserine Externalization Is a Downstream Event of Interleukin-1β–Converting Enzyme Family Protease Activation During Apoptosis Blood. ,vol. 89, pp. 2060- 2066 ,(1997) , 10.1182/BLOOD.V89.6.2060
Guy S. Salvesen, Colin S. Duckett, IAP proteins: blocking the road to death's door Nature Reviews Molecular Cell Biology. ,vol. 3, pp. 401- 410 ,(2002) , 10.1038/NRM830
Guido Kroemer, John C. Reed, Mitochondrial control of cell death Nature Medicine. ,vol. 6, pp. 513- 519 ,(2000) , 10.1038/74994
Quinn L. Deveraux, Ryosuke Takahashi, Guy S. Salvesen, John C. Reed, X-linked IAP is a direct inhibitor of cell-death proteases Nature. ,vol. 388, pp. 300- 304 ,(1997) , 10.1038/40901
Yang LiLing Yang LiLing, T Mashima, S Sato, M Mochizuki, H Sakamoto, T Yamori, T Oh-hara, T Tsuruo, Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide. Cancer Research. ,vol. 63, pp. 831- 837 ,(2003)
Srinivasa M. Srinivasula, Ramesh Hegde, Ayman Saleh, Pinaki Datta, Eric Shiozaki, Jijie Chai, Ryung-Ah Lee, Paul D. Robbins, Teresa Fernandes-Alnemri, Yigong Shi, Emad S. Alnemri, A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis Nature. ,vol. 410, pp. 112- 116 ,(2001) , 10.1038/35065125
John C. Reed, Double identity for proteins of the Bcl-2 family Nature. ,vol. 387, pp. 773- 776 ,(1997) , 10.1038/42867
Michael O. Hengartner, The biochemistry of apoptosis Nature. ,vol. 407, pp. 770- 776 ,(2000) , 10.1038/35037710
John C. Reed, Dysregulation of Apoptosis in Cancer Journal of Clinical Oncology. ,vol. 17, pp. 2941- 2941 ,(1999) , 10.1200/JCO.1999.17.9.2941
Chaohong Sun, Mengli Cai, Angelo H. Gunasekera, Robert P. Meadows, Hong Wang, Jun Chen, Haichao Zhang, Wei Wu, Nan Xu, Shi-Chung Ng, Stephen W. Fesik, NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP. Nature. ,vol. 401, pp. 818- 822 ,(1999) , 10.1038/44617