Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas
作者： G. Deng , Y. Lu , G. Zlotnikov , A. D. Thor , H. S. Smith
DOI: 10.1126/SCIENCE.274.5295.2057
关键词:
摘要: Loss of heterozygosity (LOH) was detected in morphologically normal lobules adjacent to breast cancers. The most frequent aberration at chromosome 3p22-25; ten cases with this LOH the carcinoma, six displayed same lobules. This suggests that a subset sporadic cancers, tumor suppresser gene 3p22-25 may be important initiation or early progression tumorigenesis. Among sixteen cancers 17p13.1 and five 11p15.5, one case each Thus molecular heterogeneity characterizes invasive occur earliest detectable stages progression.
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