Regulation and targets of receptor tyrosine kinases

摘要: Ligand-mediated activation of receptor tyrosine kinases (RTKs) results in autophosphorylation both the catalytic domain and noncatalytic regions cytoplasmic domain. Catalytic phosphorylation leads to potentiation kinase activity. Noncatalytic creates docking sites for downstream targets, which bind specific phosphotyrosine residues. Downstream signaling pathways are constructed a modular fashion. In addition SH2 PTB (phosphotyrosine binding) domains, signal proteins also contain domains that recognize other protein phospholipid motifs. The arrangement re-arrangement various combinations different (combinatorial use) has allowed creation complex networks pathways. performing functions, serve as scaffolds assembly multiprotein complexes, adaptors, transcription factors pathway regulators. Recent show juxtamembrane region Eph receptors is important autoregulation. Mutations several RTKs have been shown play role oncogenesis. It likely dysregulation components plays oncogenic transformation.