Increased FOXP3 expression in tumour-associated tissues of horses affected with equine sarcoid disease.
作者： K. Mählmann , E. Hamza , E. Marti , G. Dolf , J. Klukowska
DOI: 10.1016/J.TVJL.2014.09.003
关键词:
摘要: Recent studies suggest that regulatory T cells (Tregs) are associated with disease severity and progression in papilloma virus induced neoplasia. Bovine (BPV) is recognised as the most important aetiological factor equine sarcoid (ES) disease. The aim of this study was to compare expression levels Treg markers cytokines tissue samples ES-affected equids skin healthy control horses. Eleven ES-affected, 12 horses were included study. Expression forkhead box protein 3 (FOXP3), interleukin 10 (IL10), 4 (IL4) interferon gamma (IFNG) mRNA lesional tumour-distant from horses, well dermal measured using quantitative reverse transcription polymerase chain reaction (PCR). compared between samples. Furthermore, BPV-1 E5 DNA quantified PCR, possible associations viral load, gene evaluated. FOXP3, IL10 IFNG copy numbers significantly increased There no difference FOXP3 cytokine ES- In load positively correlated score. tumour-associated tissues indicates a local, Treg-induced immune suppression.
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