CA-4 derivatives as well as preparation method and medical application of CA-4 derivatives
作者： Zhang Lingzhi , Liu Kun , Chen Hongzhu , Zhu Qihua , Song Xiaohan
DOI:
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摘要: The invention relates to the field of medicinal chemistry and particularly Combretastatin A-4 derivatives (I), a preparation method application inhibition tumor angiogenesis. A pharmacological experiment result shows that compounds have relatively strong effect on inhibiting MCF-7 human breast cancer cell proliferation, meanwhile, parts also good proliferation umbilical vein endothelial cells generation new chick chorioallantoic membrane vessels. Therefore, provided by can be used for treating various diseases related angiogenesis, include cancers chronic inflammations as well other vascular diseases. favorable water solubility.
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