Prevalence of human papilloma virus in oropharyngeal, tongue and lip squamous cell carcinoma: an experience from the Egyptian National Cancer Institute.

摘要: Human papilloma virus (HPV) is now a well-known risk factor for head and neck cancer besides smoking alcohol. Most studies mentioned that patients affected with high-risk HPV cancers have better outcome, many clinical trials are trying to prove such group of can receive different less aggressive treatment than the HPV-negative group. Although field has received great interest within countries continents, African Egyptian populations not yet well studied literature. Our aim was detect prevalence in oropharyngeal (OP), lip tongue squamous cell carcinoma (SSC) correlate viral clinicopathologic parameters as patients' outcome. detection done on 99 cases from (29), (38) oropharynx (32) diagnosed at Pathology Department National Cancer Institute, Cairo University. p16 immunohistochemistry performed all cases, followed by DNA situ hybridization (ISH) p16-positive cases. The OPSSC 28% lumped together 37%. There more 90% concordance between ISH results. positivity showed statistically significant correlation disease-free survival (DFS), which also maintained OP highly prevalent common oral cavity population. correlated significantly DFS, especially cancers.